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张华山(武汉大学教授)

“冶金分析”和“分析科学学报”编委

学科专业:分析化学

研究方向: 1. 生物分子探针与检测试剂; 2.生物物质和

医药的现代分离检测(高效液相色谱和毛细管电泳)教学方面

张华山

Huashan Zhang

出生年月:1946年10月31日

学 位:理学硕士

职称职务:教授、博士生导师

(1) 化学系和药学专业本科生的“分析化学”

(2)分析化学专业硕士研究生“分子探针与检测试剂”和“稀土材料与分析”

:12名博士和2名硕士研究生(已有4名博士生毕业并获学位)

: (1)生物分子的近红外荧光标记试剂的合成、性能及应用研究,国家自然科学基金,8万,1996.1-1998.12

(2)检测和造影细胞中一氧化氮的新型荧光探针研究,国家自然科学基金,10万(2000-2002)。

(3)含二吡咯甲烷-二氟化硼基团的高灵敏生物分子荧光探针研究,教育部博士点基金,5.0万(2000-2002)。

(4)单个细胞神经递质释放的微分析系统研制,武汉科委,6万(2003-2004)。

(5)预警心血管疾病荧光探针和试剂盒的研究,湖北省科技攻关项目,2万(2003)

(6) HPLC分离荧光检测代谢物中干扰素的研究,合作项目,10.0万(2002-2004)。

:(1) 曾云鹗,张华山,陈震华,无机离子显色剂(化学工业出版社,1989);

(2) 王克谦,张华山译,Caulcutt R.(美)著,《分析工作者用统计学》,科学出版社,1989年

(3) 江祖成,蔡汝秀,张华山,《稀土元素分析化学》(第二版),科学出版社,1999年

(4) 张华山,王红,赵媛媛,分子探针和检测试剂,科学出版社,2002,北京

3.获 奖:(1)陈震华,张华山,黎心懿,曾云鹗,国家发明三等奖 (1987)

(2)程介克,刘锦春,张华山,刘良斌 国家教委科技进步奖三等奖( 1993年)

(3) 张华山,王红,黎心懿,程介克,教育部科技进步奖三等奖( 1999年)

1.Y.-Y.Zhao,H.Wang,H.-S.Zhang*,G.-Lxu,N-Hydroxysuccinimidyl-3-indolylacetate as a precolumn derivatzing reagent to separate and determine peptides and their hydrolysates by reversed-phase high performance liquid chromatography.J.Liquid Chromatogr. & Rel.Tech.,1998,21(12),1870

2.H.-S.Zhang,J-F.Zhang,H.Wang and X . -Y. Li, Synthesis and analytical application of 2,6-dichloroarsenazo as a chromogenic reagent for bismuth. Anal.Chem.Acta,1999,380(1),101.

3.Hong Wang,Hua-shan Zhang*,Jie-ke Cheng, Studies on 2-(2thiazolylazo)-5-diethylaminophenol as a precolumn derivatizing reagent in the separation of platinum group metals by high performance liquid chromatography.Talanta,1999,48(1),1

4.徐国良,王红,张华山*,N-羟基琥珀酰亚胺-a-萘乙酸酯的合成及其作为柱前衍生试剂在反相高效液相色谱中的应用。化学试剂,1999,21(1),8

5.徐国良,张华山,王红。新荧光衍生试剂N-羟基琥珀酰亚胺吲哚乙酸酯的合成、性能及应用研究。化学试剂,1999,21(1),1。

6.Hong Wang, Jin Li, Xin Liu, Ting-Xian Yang and Hua-Shan Zhang. N-hydroxysuccinimidyl fluorescein-O-acetate as a fluorescent derivatizing reagent for catecholamines in liquid chromatography. Anal. Biochem., 2000, 281, 15.

7.Hong Wang, Wei Yang, Shu-Cai Liang, Zhi-Min Zhang and Hua-Shan Zhang. Spectrofluorimetric determination of nitrite with 5, 6-diamino-1, 3-naphthalene disulfonic acid. Anal. Chim. Acta, 2000, 419(2), 169.

8.Hong Wang, Jin Li, Xin Liu and Hua-Shan Zhang. N-Hydroxysuccinimidyl fluorescein-O-acetate as a highly fluorescent derivatizing reagent for aliphatic amines in high performance liquid chromatography. Anal. Chim. Acta, 2000, 423(1), 77.

9.赵媛媛,王红,张华山。柱前衍生反相高效液相色谱分离和测定氨基酸-用N-羟基琥珀酰亚胺-3-萘乙酸酯作衍生试剂。分析科学学报,2000,16(3),188。

10.李进,王红,曹启花,张华山。某些变色酸偶氮类染料与蛋白质作用的分光光度研究。化学试剂,2000,22(3),129。

11.Hong Wang, Wei-Sheng Wang and Hua-Shan Zhang. Spectrofluorimetic determination of cysteine based on the fluorescence inhibition of Cd(II)-8-hydroxyquinoline-5-sulphonic acid complex by cysteine. Talanta, 2001, 53, 1015.

12.Xin Liu, Hong Wang, Shu-Cai Liang, Hua-Shan Zhang. 4:3-b-Naphthapyrone-4-acetic acid N-hydroxysuccinimidyl ester as a fluorescent labeling reagent for amino acids and oligopeptides in high performance liquid chromatography. Chromatographia, 2001, 53(5/6), 326-330.

13.Xin Liu, Hong Wang, Shu-Cai Liang, Hua-Shan Zhang. Determination of primary and secondary aliphatic amines by N-hydroxysuccinimidyl 4, 3, 2’-naphthapyrone-4-acetate and reversed-phase high-performance liquid chromatography. Anal. Chim. Acta, 2001, 441, 45-52.

14.Shu-Cai Liang, Hong Wang, Zhi-Min Zhang, Yu-Yang Zhou, Hua-Shan Zhang. Spectrofluorimetic determination of thiols by N-[p-(2-benzoxazolyl)phenyl]maleimide. Fresenius’ J. Anal. Chem., 2001, 370, 1117-1119.

15.Hong Wang, Jin Li, Ting-Xian Yang, and Hua-Shan Zhang, N-Hydroxysuccinimidyl-fluorescein-O-acetate for precolumn fluorescence derivatization of amino acids and oligopeptides in liquid chromatography. J. Chromatogr. Sci., 2001, 39, 365-369.

16.Hong Wang, Wei-Sheng Wang and Hua-Shan Zhang. A spectrofluorimetric method for cysteine and glutathione using the fluorescence system of Zn(II)-8-hydroxyquinoline-5-sulphonic acid complex. Spectrochim. Acta, Part A, 2001, 57, 2403-2407.

17.Hong Wang, Yuan-Yuan Zhao, Hong Jin, Hua-Shan Zhang N-Hydroxysuccinimidyl-a-naphthylacetate as a derivatizing reagent for amino acids and oligopeptides in reversed-phase high performance liquid chromatography, J. Liq. Chromatogr. Rel. Technol., 2001, 24(20), 3157-3170.

18. ZHANG XIAN ,WANG HONG,ZHANG HUA SHAN, Spectrofluorimetric determination of magnesium with 7-(8- hydro xy-3,6-disulfonaphthylazo)-8-hydroxyquinoline-5-sul-fonic acid WUHAN UNIVERSITY JANURUAL OF NATURALSCIENCE,6(4),83(2001),

19.Yuan-Yuan Zhao, Zhi-Zhong Jing, Hua-Shan Zhang*,The determination of impurities in caprolactam by capillary gas chrimatography-mass spectrometry,Microchemical Journal,2001, 69, 213-217

20.Shu-Cai Liang, Hong Wang, Zhi-Min Zhang, Xian Zhang, Hua-Shan Zhang. Direct spectrifluorimetric determination of glutathione in biological samples using 5-malermidyl-2-(m-methylphenyl) benzoxazole. Anal. Chim. Acta, 2002, 451(2), 211-219.

21.Xian Zhang, Hong Wang, Shu-Cai Liang, Hua-Shan Zhang. Spectrofluorimetric determination of nitric oxide at trace levels with 5, 6-diamino-1, 3-naphthalene disulfonic acid. Talanta, 2002, 56(3), 499-504.

22. 黄文胜,王红,张军锋,张华山,三氯偶氮氯膦测定铋的显色反应研究, 分析科学学报,18(3),199(2002)

23.黄文胜,王红,张军锋,张华山,新显色剂2,6-二碘-4-硝基偶氮氯磷光度法测定铋的研究,分析化学,30(4),470(2002)

24.黄文胜,王红,张军锋,张华山,新显色剂间氟偶氮氯磷分光光度法测定铋的研究,冶金分析,22(12),6(2002)

25. 黄文胜,王红,张军锋,张华山,三氯偶氮氯膦测定铋的显色反应研究,分析科学学报,18(3),(2002)

26.Shu-Cai Liang, Hong Wang ,Zhi-min Zhang,Xian Zhang,Hua-shan Zhang,Spectrofluorimetric determination of cysteine by 5-maleimidyl-2-(m-methylphenyl)benzoxazole, Spectrochimica Acta A,58,2605(2002)

27.Y.-Y.Zhao,Zhi-zhong Jing Hong.Wang,Hua-shan Zhang*, N-Hydroxysuccinimidylphenylacetate as a novel derivatizing reagent for aliphatic amines in gas chromatography,Anal. Chim. Acta, 468,255(2002).

28. Zhen Shen, Hong Wang, Shu-cai Liang, Zhi-Min zhang, and Hua-Shan Zhang, Spectrofluorimetric Determination of Reduced Glutathione in Human Blood Using N-[p-(2-benzothi azoyl)-phenyl]maleimide, Analytical Letters,35,(14),2269(2002)

29.Hua LI, Hong WANG, Jin-he CHEN, Li-hua WANG, Hua-shan ZHANG*, Yun FAN, “Determination of amino acid neurotransmitters in cerebral cortex of rats administered with baicalin prior to cerebral ischemia by capillary electrophoresisllaser-induced fluorescence detection, J. Chromatogr. B, 788,93(2003)

30.J-F Zhang,H.Wang,A-X Hou,C-F Wang,H-S Zhang,Speciacion of thulium porphyrin complexes by reversed-phase HPLC,26(6),911(2003)

31.Xian Zhang,Hong Wang,Jinshu Li, Hua-shan Zhang,Development of a fluorescent probe for nitric oxide detection based on difluoroboradiaza-s-indacene fluorophore,Anal.Chim.Acta,481,101(2003)

32. Xian Zhang,Hong Wang,Ni-na Fu, Hua-shan Zhang,A fluorescence quenching method for the determination of nitrite with rhodamine 110, Spectrochimica Acta A,59,1667(2003)

33. Li-wei Cao, Xin Liu, Hong Wang, Hua-Shan Zhang. Spectrofluorimetric determination of aliphatic amines using a new fluorigenic reagent:2,6 -dimehtylquinoline-4-(N- succinimidyl)-formate,Talanta,56,973(2003).


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