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杨志荣(四川大学生物资源与生态环境实验室副主任)

杨志荣,博士,教授。四川大学生物资源与生态环境教育部重点实验室副主任,四川省学术技术带头人选,国家自然科学基金评议专家.

在国内外首次分离发现了草原毛虫核型多角体病毒、栗黄枯叶蛾核型多角体病毒、盗毒蛾核型多角体病毒等三种昆虫病毒;一种新的昆虫病原微生物——类产碱假单胞菌;从该昆虫病原微生物中发现了一种新的杀虫蛋白;并成功地克隆到该杀虫蛋白基因,该基因已获得国家发明专利;并将该杀虫基因成功地构建了具有杀虫效果的抗虫转基因牧草新材料,抗虫转基因牧草新材料已经获得了国家发明专利。 在人类肿瘤的发生机制与肿瘤治疗研究方面,探明了大肠癌的一种发生机制,该研究结果于2010年发表在美国科学院院报(PNAS),该研究结果在国内外都引起了巨大反应;在真菌研究方面,应用真菌多糖治疗肿瘤的研究,取得了很好的结果,研制出三种真菌多糖保健品。 在国内外首次研制出草原毛虫核型多角体病毒杀虫剂和细菌灭蝗剂,现已获得国家新农药登记,并在青藏高原草地大面积应用于草原毛虫和蝗虫防治;应用肉毒梭状芽孢杆菌产生的A型肉毒毒素研制成生物灭鼠剂防治草原鼠害,长期在青藏高原草地大面积应用。 从2000年以来,从事生态环境保护的研究与应用,成功地研究出青藏高原退化草地和沙化草地的治理模式与治理技术体系;高寒退化湿地生态系统恢复模式与恢复技术体系。 [1]

研究方向


  遗传学、生物技术、基因工程、动物免疫学、动物传染病和微生物学;

利用我国丰富的生物资源,克隆分离相关功能基因,鉴定其功能活性;以现代分子生物学、生物信息学、结构生物学和分子免疫学等理论为指导,用生物工程技术重组改造其结构,提高其表达产物生物调节活性,研制防治动物传染性疾病的新型动物抗病基因制剂,研发新型生物制剂控制生物病害和微生物感染,保障和促进动物健康生长,并改善动物营养成分,提高其营养价值。

先后主持国家级科研项目10余项、国家自然科学基金4项、省部级科研项目20多项。现主持国家支撑计划项目1项(生物源毒鼠药剂的研发与应用,经费:175万元),四川省科技支撑计划项目2项(若尔盖湿地保护的关键技术研究与示范,经费:50万元;甘孜、阿坝种植中药材生态治沙关键技术与示范,经费:300万元),横向合作项目1项。作为主研人员参加的国家的国际合作项目1项, 省部级项目3项。 [2]


  2006年以来发表的部分重要学术论文(仅列SCI收录论文)
  (1) Qiang Luo, Qun Sun, Lisa Wu, Zhirong Yang. Structural characterization of an immunoregulatory polysaccharide from the fruiting bodies of Lepista sordida. Carbohydrate Polymers. doi:10.1016/j.carbpol.2011.12.0433. (通讯作者) (2) Fan Luo, Su Feng, Qun Sun, Wenliang Xiang, Jian Zhao, Jie Zhang, Zhirong Yang, srceening for bacteriocin-producing lactic acid bacteria from kurut, a traditional naturally-fermented yak milk from QinghaieTibet plateau. Food Control, 2011, 22:50-53. (通讯作者)
  (3) Qiang Luo, Jie Zhang, Liang Yan, Yuanlin Tang, Xiang Ding, Zhirong Yang, and Qun Sun. Composition and Antioxidant Activity of Water-Soluble Polysaccharides from Tuber indicum. Journal of Medicinal Food. 14 (0) 2011, 18.
  (4) Xiang Ding, Su Feng, Mei Cao, Maotao Li, Jie Tang, Chun-xiao Guo, Jie Zhang,Qun Sun, Zhirong Yang, Jian Zhao. Structure characterization of polysaccharide isolated from the fruiting bodies of Tricholoma matsutake. Carbohydrate Polymers, 2010, 81:942-947.
  (5) Yiqing Zhao, Xiaodong Zhang, Kishore Guda, Earl Lawrence, Qun Sun, Toshio Watanabe, Yoichiro Iwakura, Masahide Asano, LanlanWei, Zhirong Yang,Weiping Zheng, Dawn Dawson, JosephWillis, Sanford D. Markowitz, Masanobu Sataked, and Zhenghe Wang. Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. Proceedings of the National Academy of Sciences (PNAS), 2010, 107: 2592-2597.
  (6) Wei Wei, Linyong Zheng, Mengyao Yu, Nan Jiang, Zhirong Yang, Xia Luo. Anti-fatigue activity of extract form the submerged fermentation of Ganoderma Lucidum using Radix astragali as substrate. Journal of Animal & Plant Sciences, 2010, 6: 677- 684.
  (7) Linyong Zheng, Dinghong Jia, Xiaofan Fei, Xia Luo, Zhirong Yang, An assessment of the genetic diversity within Ganoderma strains with AFLP and ITS PCR-RFLP. Microbiological Research, 2009, 164: 312-321. (通讯作者)
  (8) Mengyao Yu, Xiaoyan Xu, Yuan Qing Xia Luo, Zhirong Yang, Linyong Zheng. Isolation of an anti-tumor polysaccharide from Auricularia polytricha (jew’s ear) and its effects on macrophage activation. Eur Food Res Technol, 2009, 228: 477485.
  (9)Mei Zeng Yilu Lu1, Xiaolin Liao1, Dan Li Huaqin Sun1, Suhua Liang Sizhong Zhang1, Yongxin Ma and Zhirong Yang ,DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression MOLECULAR BIOLOGY REPORTS 卷: 36 期: 8 页: 2009 2399-2403
  (10)Hao Chen Chaorong Peng , Yongyi Yao Jingxia Wang Zhuping Chen Zhirong Yang Lijun Xia Siyang Liu ,Preparation and Characterization of poly(L-lactide) Membranes Prepared by gamma-Radiation-Induced Grafting of N-Vinyl Pyrrolidone JOURNAL OF APPLIED POLYMER SCIENCE 5 2009 3152-3157
  (11)Jiang LH, Shi Y, Wang LS, Yang ZR ,The influence of orally administered docosahexaenoic acid on cognitive ability in aged mice JOURNAL OF NUTRITIONAL BIOCHEMISTRY 2009 735-741
  (12)Chen Q, Cao M, Xiang WL, Sun Q, Zhang J, Hou RT, Yan ZY, Yang ZR, Liu J, Zhao J.,STUDY ON GENES WITH ALTERED EXPRESSION IN alpha-AMANITIN POISONED MICE AND EVALUATION ON ANTAGONISTIC EFFECTS OF TRADITIONAL CHINESE MEDICINES AGAINST TOXICITY OF alpha-AMANITIN ACTA BIOLOGICA HUNGARICA 2009 281-291
  (13)Jie Zhang Jian Zhao Daxu Li Sujun Liu1, Li Li Qun Sun1, Ming Huang and Zhirong Yang, Cloning of the gene encoding an insecticidal protein in Pseudomanas pseudoalcaligenes ANNALS OF MICROBIOLOGY 2009 45-50
  (14)Huang Min Da-Xu Li Wen-Liang Xiang Chen Hao Jian-Hua Guo Zhao Jian Zhang Jie Zhi-Rong Yang Sun Qun ,
  Effect of the untranslated region and signal peptide sequence of the insecticidal gene from Pseudomonas pseudoalcaligenes on the activity of its expression products in tobacco WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2009 619-625
  (15)Wenliang Xiang Jianhua Guo Wei Feng Min Huang Hao Chen Jian Zhao Jie Zhang Zhirong Yang1 and Qun Sun,Community of extremely halophilic bacteria in historic Dagong Brine Well in southwestern China WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2008 2297-2305
  (16)GUO Jian-Hua ; XIANG Wen-Liang ; ZHAO Qing-Rong ; TAO LUO ; MIN HUANG ; JIE ZHANG ; JIAN ZHAO ; YANG Zhi-Rong ; QUN SUN Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates from Sichuan Province in China JAPANESE JOURNAL OF INFECTIOUS DISEASES 2008 264-268
  (17)Luo X (Luo, Xia) Xu XY Yu MY) Yang ZR Zheng LY ,Characterisation and immunostimulatory activity of an alpha-(1 -> 6)-D-glucan from the cultured Armillariella tabescens mycelia FOOD CHEMISTRY 15 2008 357-363
  (18)Zou LK , Wang HN Pan X Tian GB Xie ZW Wu Q Chen H Xie T Yang ZR Expression, purification and characterization of a phyA(m)-phyCs fusion phytase JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE 2008 536-545
  (19)Zeng M Sun HQ Chen S Wang XY Yang Y Liu YQ Tao DC Yang ZR Zhang SZMa YX ,Identification of target messenger RNA substrates for mouse RBMY OLECULAR HUMAN REPRODUCTION 2008 331-336
  (20)Zhe R Zhang MY Kitazato K Kobayash N Zhu QC Zhang PZ Yang ZR Wang YF , Effect of siRNA on HSV-1 plaque formation and relative expression levels of UL39 mRNA ARCHIVES OF VIROLOGY 2008 1401-1406
  Effect of siRNA on HSV-1 plaque formation and relative expression levels of UL39 mRNA
  (21)Chen S, Xin Y, Zhan Y, Yang ZR. Synthesis and antimicrobial activities of brominated dihydroxy nitro diphenyl ethers CHINESE JOURNAL OF ORGANIC CHEMISTRY 2008 498-502
  (22) Mengyao Yu Bo Ma1, Xia Luo Linyong Zheng Xiaoyan Xu and Zhirong Yang ,Molecular diversity of Auricularia polytricha revealed by inter-simple sequence repeat and sequence-related amplified polymorphism markers CURRENT MICROBIOLOGY
  2008 240-245
  (23)Hai-Long Sun, Shao-Cai Li Wen-Lan Xiong Zhi-Rong Yang, Bao-Shan Cui and Tao-Yang ,Influence of slope on root system anchorage of Pinus yunnanensis ECOLOGICAL ENGINEERING 3 2008 60-67
  (24)邹燕 吴洁,侯若彤,吴凯群, 王玉良,陈淑华,杨志荣,王玉忠,Study on the synthesis and bactericidal activities of new brominated hydroxy diphenyl ether CHINESE JOURNAL OF ORGANIC CHEMISTRY 2008 111-114
  (25)Shu-Lin Zhang, Jian-Guo Shen, Gwan-Han Shen, Zhan-Qiang Sun, Ping-Hui Xu, Yi-Li Peng, Zhi-Rong Yang and Qun Sun ,Use of a novel multiplex probe array for rapid identification of Mycobacterium species from clinical isolates WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2007 1779-1788 出版年:
  (26)Zhang SL , Shen JG, Xu PH, Li DX, Sun ZQ, Li L, Yang ZR, Sun Q A novel genotypic test for rapid detection of multidrug-resistant Mycobacterium tuberculosis isolates by a multiplex probe array JOURNAL OF APPLIED MICROBIOLOGY 2007 1262-1271
  (27)Jin D, Lu W, Ping SZ, Zhang W, Chen J, Dun BQ, Ma RQ, Zhao ZL, Sha JY, Li L, Yang ZR, Chen M , Lin M ,Identification of a new gene encoding EPSPS with high glyphosate resistance from the metagenomic library CURRENT MICROBIOLOGY 2007350-355
  (28)Li SC , Sun HL, Yang ZR, Xiong WL, Cui BS Root anchorage of Vitex negundo L. on rocky slopes under different weathering degrees ECOLOGICAL ENGINEERING 1 2007 27-33
  (29)Zhang SL, Qi H (, Qiu DL, Li DX, Zhang J, Du CM, Wang GB, Yang ZR, Sun Q ,Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates recovered from Central China BIOCHEMICAL GENETICS 2007281-290
  (30)Zhao J, Cao M, Zhang J Yang ZR ,Pathological effects of the mushroom toxin alpha-amanitin on BALB/c mice PEPTIDES 2006 3047-3052
  (31)Zhao J , Cao M, Zhang J, Sun Q, Chen Q, Yang ZR ,Cloning and expression of a 5-enolpyruvylshikimate-3-phosphate synthase gene from Halomonas variabilis DNA SEQUENCE 208-214 2006
  (32)Jin H, Chen S, Hou RT, Wang YL, Chen SH, Yang ZR Study on the synthesis and antimicrobial activities of brominated dihydroxy diphenyl ethers CHINESE JOURNAL OF ORGANIC CHEMISTRY 2006 1424-1428
  (33)Liu SJ, Luo X, Li DX, Zhang J, Qiu DL, Liu W, She LA, Yang ZR, Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC INTERNATIONAL IMMUNOPHARMACOLOGY : 2006 1387-1393
  (34)Liu Z, Lu W, Chen M, Yang ZR, Lin M ,Genetic analysis of glyphosate tolerance in Halomonas variabilis strain HTG(7) WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2006 681-686
  (35)Li L, Zhang J, Zhu JQ, Gu S, Sun Q, Zhou GM, Fu CX, Li Q, Yang ZR, Genetic diversity of nine populations of the black goat (Capra hircus) in Sichuan, PR china ZOOLOGICAL SCIENCE 2006 229-234 出版年:
  (36)Li DX, Zhang J, Zhao J, Zhang Y, Chen F, Zhu JQ, Liu SJ, Yang ZR, Plant regeneration via somatic embryogenesis of Elymus sibiricus cv. 'chuancao No. 2' PLANT CELL TISSUE AND ORGAN CULTURE 2006 285-292
  (37) Yi Y, Cao Y, Li Q, Liu M, Cheng L, Bai LH, Yang ZR, Qiao DR, Cloning and sequence analysis of the gene encoding (6-4)photolyase from Dunaliella salina BIOTECHNOLOGY LETTERS 2006 309-314
  (38)Ke YP, Sun Q, Yang ZR, Xin JJ, Chen L, Hou XD, Determination of trace cadmium and zinc in corn kernels and related soil samples by atomic absorption and chemical vapor generation atomic fluorescence after microwave-assisted digestion SPECTROSCOPY 2006 29-43 [3]

在动物免疫学和疫苗(常规疫苗、基因工程重组疫苗和核酸疫苗等)免疫应答研究方面,作为主研人员获省部级科技进步二等奖4项,省教委科技进步一等奖2项、二等奖1项;主持或主研了国家自然科学基金、国家863计划、国家重大基础项目等共10项国家级课题和15项教育部、四川省重点科研课题研究

《鸡传染性法氏囊病的免疫机理》,黑龙江省科技进步二等奖,黑龙江省教委科技进步一等奖,1994年。

《鸡马立克氏病及其疫苗的免疫机理》,黑龙江省科技进步二等奖,黑龙江省教委科技进步一等奖,1996年。

《小日龄火鸡新城疫免疫机理研究》,黑龙江省教委科技进步一等奖,1999年。

《猪囊虫病防治关键技术研究》,四川省科技进步二等奖,2000年

已申报国家技术发明专利10项

1)猪白细胞介素-2基因抗感染制剂的制备及应用,申请号:200410040210.X

2)细胞介素-6基因抗感染免疫增强剂的制备和应用,申请号:200410040699.0

3)猪白细胞介素-4、6融合基因抗病制剂,申请号:200410040763.5

4)融合猪免疫基因抗感染纳米分子制剂的制备和应用,申请号:200410040749.5

5)CpG DNA分子抗感染免疫制剂的制备和应用,申请号:200410040701.4

6)猪白细胞介素-4基因抗病制剂的制备和使用技术,申请号:200410040700.X

7)CpG寡聚核苷酸抗感染DNA制剂的制备及应用技术,申请号:200410040209.7

8)猪白细胞介素6基因与CpG分子融合抗感染免疫制剂的制备及应用,申请号:200510021954.1

9)复合猪白细胞介素基因抗感染纳米分子制剂的制备和应用,申请号:200510021955.6

10)10、新型猪白细胞介素2和6基因表达质粒抗感染制剂的应用技术,申请号:200510021956.0


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