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张锦生

张锦生,江苏丹徒人,复旦大学医学院病理学教授。1962年考入上海第一医学院医学系,1968毕业,以后分到西北农村为医生近十年。1978年考回上海第一医学院攻读硕士,1985年上海医科大学研究生院病理学专业研究生毕业,获博士学位。1988年至1990年获美国NIH福格地(Fogarty)博士后研究奖学金赴美国Wisconsin大学McArdle癌症研究所进行博士后研究。1995年赴瑞士洛桑大学医学院病理研究所进修分子病理。目前是中华医学杂志(英文版)编委。1996年批准为博士生导师。

(1)TI: [The pathological bases for the increase of serum alpha-fetoprotein level during hepatocarcinogenesis in rats] AU: Zhang,-J-S SO: Zhonghua-Bing-Li-Xue-Za-Zhi. 1987 Dec; 16(4): 278-80,

(2)TI: DNA damage and repair in gamma-glutamyltranspeptidase-positive and negative hepatocytes in primary culture from carcinogen-treated rats. AU: Zhang,-J-S; Xu,-Y-H; Sattler,-G-L; Pitot,-H-C SO: Proc-Soc-Exp-Biol-Med. 1991 Jan; 196(1): 47-53

(3)TI: Genetic diversity at the p53 locus between primary human colorectal adenocarcinomas and their lymph-node metastases. AU: Zhang,-J-S; Caplin,-S; Bosman,-F-T; Benhattar,-J SO: Int-J-Cancer. 1997 Mar 17; 70(6): 674-8

(4)TI: [Effects of heparin on the growth, extracellular matrix and matrix metalloproteinase gene expression in rat hepatic stellate cells] AU: Li,-W; Zhang,-J; Huang,-G; Zhu,-H; Zhang,-X; Zhang,-Y SO: Zhonghua-Gan-Zang-Bing-Za-Zhi. 2000 Aug; 8(4): 200-2

(5)TI: [Evidence for retinoic acid modulating expression of cyclin-dependent kinase inhibitors in rat hepatic stellate cells] AU: Huang,-G; Zhang,-J; Zhang,-Y SO: Zhonghua-Gan-Zang-Bing-Za-Zhi. 2001 Oct; 9(5): 306-8

(6)TI:[Expression of CCAAT/enhancer-binding protein in cultured rat hepatic stellate cells and its significance] AU:Huang J, Zhang JS, Huang GC, Tang QQ, Chen C, Zhang XR, Chen Zhonghua Gan Zang Bing Za Zhi. 2004 May;12(5):259-62.

(7)TI:[Effects of platelet-derived growth factor on the proliferation of hepaticstellate cells and their expressions of genes of collagens and platelet-derivedgrowth factor]AU:Liu X, Zhang J, Zhang Y.

SO:Zhonghua Bing Li Xue Za Zhi. 2000 Feb;29(1):27-9.

(8)TI:[Effect of RAR-beta transfection on the proliferation and phenotype of rat hepatic stellate cells]

AU:Li H, Zhang JS, Huang GC, Zhang N, Chen Q, Zhang Zhonghua Gan Zang Bing Za Zhi. 2002 Aug;10(4):297-300.

(9)TI:[Effect of retinoid receptor alpha (RXRalpha) transfection on the proliferation and phenotype of rat hepatic stellate cells in vitro.]AU:Li H, Zhang J, Huang G, Zhang N, Chen Q, Zhang X. SO:Chin Med J (Engl). 2002 Jun;115(6):928-32.

(10)TI:[Hydrodynamic-based in vivo transfection of retinoic X receptor-alpha gene can enhance vitamin A-induced attenuation of liver fibrosis in mice.]AU:Chen C, Zhang J, Li J, Huang J, Yang C, Huang G, Shi :Liver Int. 2004 Dec;24(6):679-86.

(11)TI:[Involvement of C/EBP-alpha gene in in vitro activation of rat hepatic stellate cells. ]AU:Huang GC, Zhang JS, Tang :Biochem Biophys Res Commun. 2004 Nov 26;324(4):1309-18.

(12)TI:[Effects of retinoic acid on proliferation, phenotype and expression of cyclin-dependent kinase inhibitors in TGF-beta1-stimulated rat hepatic stellate cells.] AU:Huang GC, Zhang JS, Zhang :World J Gastroenterol. 2000 Dec;6(6):819-823。

担任病理学的教学与科研工作。研究方向为肝病病理,从事实验性肝癌癌变机理研究、肝纤维化发生机理的研究。发表论文36篇。

主编和参编《现代组织化学的原理及应用》、《原发性肝癌》、《实用肿瘤病理方法学》等专著及教材5册。

科研成果主要有“细胞外基质及间质细胞的病理生物学研究”,1995年获上海市科学技术进步二等奖和卫生部科学技术进步三等奖。培养研究生7名,已毕业博士生1名、硕士生两名,在学博士生三名、硕士生一名。

1991曾获国家教委授予的“有突出贡献的中国博士学位获得者”称号,2003年被国务院学位办选为基础医学学科评议组成员。


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