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周天华(浙江大学教授)

周天华,男,1970年出生,博士,教授,博士生导师,“教育部新世纪优秀人才计划”获得者。工作领域:1、细胞周期与细胞运动的分子调控机制 2、胃癌发病机理及其分子靶向治疗研究 3、miRNA在癌症中的作用及机制。

1993年获浙江大学医学院临床医学学士学位。

1996年获浙江大学医学院临床医学硕士学位。

1999年获中国科学院上海生命科学院生物化学和细胞生物学研究所理学博士学位。

2000年赴美国哈佛大学分子细胞生物学系进行博士后训练。

2005年回国在浙江大学医学院任教,现任浙江大学基础医学系副主任。

中国细胞生物学学会精细细胞结构与功能分会 秘书长

浙江省细胞生物学学会 常务理事

Cell Research (影响因子9.417)编委

细胞运动和细胞周期分子调控及其在胃癌发病中的作用。

其在分子细胞生物学和分子肿瘤学等领域,具有比较扎实的理论知识和实践基础,自1997年以来,已在《Dev Cell》(Cell 子刊)、《PNAS》(美国国家科学院院刊)和《J Biol Chem》等国际学术期刊发表了20多篇原始学术论文,合计影响因子超过100,受到国际同行们的关注(已被国际学术杂志引用了数百次)。2009年起,其领导的研究小组在细胞运动分子机理调控及人类重大疾病发生发展的细胞运动基础等领域,取得了一些有价值的实验结果,在《PNAS》等国际著名刊物上发表了一系列的原创性学术文章。其研究工作受到国家自然科学基金、国家高技术研究发展计划(863计划)、国家重点基础研究发展计划(973计划)等项目的资助。

作为通讯作者和第一作者的主要论文(* 通讯作者):

1. Xu Y, Deng Y, Yan X and Zhou T*. Targeting miR-375 in gastric cancer. Expert Opinion on Therapeutic Targets. (doi:10.1517/14728222.2011.581232) May 2011.(最新影响因子: 3.649)

2. Zhu X, Liu X, Jin Q, Cai Y, Yang Y and Zhou T.* (2010). The L279P Mutation of Nuclear Distribution Gene C (NudC) Influences Its Chaperone Activity and LIS1 Stability. Journal of Biological Chemistry 285(39):29903-29910. (最新影响因子: 5. 328)

3. Ding L, Xu Y, Zhang W, Deng Y, Si M, Du Y, Hao H, Liu X, Si J and Zhou T.* (2010). MiR-375 Frequently Down-regulated in Gastric Cancer Inhibits Cell Proliferation by Targeting JAK2. Cell Research 20(7):784-793. (最新影响因子: 9.417)

4. Yang Y, Yan X, Cai Y, Lu Y, Si J* and Zhou, T.* (2010). NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. Proceedings of the National Academy of Sciences of the United States of America 107(8): 3499-3504. (最新影响因子: 9.771)

5. Cai Y, Yang Y, Shen M and Zhou T.* (2009) Inhibition of cytokinesis by overexpression of NudCL that is localized to the centrosome and midbody. Cell Research 19(11):1305-1308. (当年影响因子: 8.151)

6. Du Y, Xu Y, Ding L, Yao H, Yu H, Zhou T* and Si M.* (2009) Down-regulation of miR-141 in gastric cancer and its involvement in cell growth. Journal of Gastroenterology 44(6):556561. (当年影响因子: 2.909)

7. Zhou T, Zimmerman W, Liu X and Erikson RL. (2006). A Mammalian NudC-Like Protein Essential for Dynein Stability and Cell Viability. Proceedings of the National Academy of Sciences of the United States of America 103(24):9039-9044. (当年影响因子: 9.643)

8. Zhou T,* Aumais J, Liu X, Yu-Lee, LY and Erikson, RL. (2003). A role for Plk1 phosphorylation of NudC in cytokinesis. Developmental Cell 5(1):127-138. (当年影响因子: 14.807)

9. Zhou TH, Ling K, Guo J, Zhou H, Wu Y, Jing Q, Ma L and Pei G. (2000). Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. Journal of Biological Chemistry 275(4):2513-2519. (当年影响因子: 7.368)

10. Wu GX,# Lin YM, # Zhou TH, # Gao H and Pei G. (2000). Significant down-regulation of alpha-albumin in human hepatoma and its implication. Cancer Letters 160(2), 229-236. (#共同第1作者,当年影响因子: 1.517)

11. Zhou TH, Ren XH, Yin DL, Wu YL, Li M, Lu CZ, Wu DC, Wu YQ, Peng YQ, Wang YP, Ma L and Pei G. (1997). Retardation of pain development: a case of recovery from congenital insensitivity to pain. Acta Anaesthesiologica Scandinavica 41, 1077-1079. (当年影响因子: 1.953)

作为合作作者的主要论文:

12. Gan L, Chen S, Zhong J, Wang X, EK Lam, Liu X, Zhang J, Zhou T, Yu J, Si J, Wang L, and Jin H. (2011). ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer. PloS One 6(2): e16916. (最新影响因子: 4.610)

13. Zhou Q, Lu X, Gan L, Chen S, Zhou T, Wang L and Si J. (2010). Role of REG Iα in gastric carcinogenesis: Gastrin-associated proliferative and anti-apoptotic activities. Molecular Medicine REPORORTS 3(6): 999-1005. (最新影响因子: 0.307)

14. Li A, Zhou T, Guo L, Si J. (2010) Collagen type I regulates beta-catenin tyrosine phosphorylation and nuclear translocation to promote migration and proliferation of gastric carcinoma cells. Oncology Reports 23(5):1247-1255. (最新影响因子: 1.686)

15. Zhao Y, Zhou T, Yao H, Hei F, Wang L and Si M. (2009) A Potential Role of Collagens Expression in Distinguishing between Premalignant and Malignant Lesions in Stomach. The Anatomical Record 292(5):692-700. (当年影响因子: 1.490)

16. Chen Y, Chen Y, Liu WL, Zhou TH, Cai JT, Du Q, Wang LJ, Wu JG and Si JM. (2009). Therapeutic effects of rectal administration of muscovite on experimental colitis in rats. Journal Gastroenterology and Hepatology 24(5):912-919. (当年影响因子: 2.317)

17. Pan H, Sheng JZ, Tang L, Zhu R, Zhou TH and Huang HF. (2008). Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients. Fertility & Sterility 90(4):1000-1007. (当年影响因子: 4.167)

18. Li M, Zhou TH, Gao Y, Zhang N and Li JC. (2007). Ultrastructure and estrogen regulation of the lymphatic stomata of ovarian bursa in mice. The Anatomical Record 290(10):1195-1202. (当年影响因子: 1.800)

19. Liu WL, Chen SJ, Chen Y, Sun LM, Zhang W, Zeng YM, Zhou TH and Si JM. (2007). Protective effects of heat shock protein70 induced by geranylgeranylacetone in atrophic gastritis in rats. Acta Pharmacology Sinica 28(7):1001-1006. (当年影响因子:1.677)

20. Liu AX, Jin F, Zhang WW, Zhou TH, Zhou CY, Yao WM, Qian YL and Huang HF. (2006). Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss. Biology of Reproduction 75(3):414-420. (当年影响因子:3. 498)

21. Liu X, Lin CY, Lei M, Yan S, Zhou T and Erikson RL. (2005). CCT chaperonin complex is required for the biogenesis of functional Plk1. Molecular and Cellular Biology 25(12):4993-5010.(当年影响因子: 7.093)

22. Liu X, Zhou T, Yan S and Erikson RL. (2004). Molecular interaction of polo-like kinase 1 with mitotic kinesin-like protein CHO1/MKLP-1. Journal of Cell Science 117(15):3233-3246. (当年影响因子: 6.910)

23. Liu X, Yan S, Zhou T, Terada Y and Erikson RL. (2004). The MAP kinase pathway is required for entry into mitosis and cell survival. Oncogene 23(3): 763-776. (当年影响因子: 6.318)

24. Wang P, Wu Y, Zhou TH, Sun Y and Pei G. (2000). Identification of alternative splicing variants of the beta subunit of human Ca (2+)/calmodulin-dependent protein kinase II with different activities. FEBS Letters 475(2):107-110. (当年影响因子: 3.440)

25. Yu QM, Cheng ZJ, Zhou TH, Cen B, Guo SQ and Pei G. (1999). Molecular cloning of human beta arrestin1 cDNA, expression and function study. Acta Biochimica et Biophysica Sinica 31(3):344-346. (最新影响因子: 1.547)

26. Lou LG, Zhou T, Wang P and Pei, G. (1999). Modulation of Ca2+/Calmodulin-Dependent Protein Kinase II Activity by Acute and Chronic Morphine Administration in Rat Hippocampus: Differential Regulation of and Isoforms. Molecular Pharmacology 55(3):557-563. (最新影响因子: 4.725)

27. Fan GH, Zhou TH, Zhang WB and Pei G. (1998). Suppression of Phospholipase C blocks Gi-mediated inhibition of adenylyl cyclase activity. European Journal of Pharmacology 341(2), 317-322. (最新影响因子: 2.737)

28. Yu QM., Cheng ZJ, Zhao J, Zhou TH, Wu YL Ma L and Pei G. (1998). Carboxyl terminal of rhodopsin kinase is required for the phosphorylation of photo-activated rhodopsin. Cell Research 8(4),:303-310. (最新影响因子: 9.417)

29. Wu Y L, Fan GH, ZhaoJ, Zhou TH, Ma L and Pei, G. (1997). Functional expression of Opioid receptor-like Receptor and its endogenous specific agonist Nociceptin/Orphanin FQ during Mouse embryogenesis. Cell Research 7(2):207-215. (最新影响因子: 9.417)

1. Zhou, T. and Erikson, R.L. A role of Polo-like kinase 1 phosphorylation of NudC in cytokinesis. In Signal Transduction of Cell Division, T. Miki, ed. (Research Signpost). (2005).

在美国基因数据库(GenBank)登录的基因:

FJ215684 (Homo sapiens NudC-like protein 2),

AF083420 (homo sapiens brain-specific STE20-like protein kinase 3, MST3b),

AF078803 (homo sapiens calcium/calmodulin-dependent protein kinase 2 beta subunit),

AF081924 (homo sapiens calcium/calmodulin-dependent protein kinase 2 beta 6 subunit),

AF140350 (Homo sapiens calcium/calmodulin-dependent protein kinase II beta 7 subunit),

AF083419 (homo sapiens calcium/calmodulin-dependent protein kinase beta 2 e subunit),

AF081572 (homo sapiens calcium/calmodulin-dependent protein kinase 2 beta e’ subunit),

AF091486 (homo sapiens calcium/calmodulin-dependent protein kinase 2 alpha subunit),

AF084040 (homo sapiens beta-arrestin 1A),

AF084940 (homo sapiens beta-arrestin 1B),

AF106941 (homo sapiens beta-arrestin 2).

1. 美国专利“Method for detecting liver cell in peripheral blood” (专利证书号:CN1331417-A,排名第三)

1、胃癌前病变癌变准确监测和有效阻断技术体系的建立(2009年中华医学科技奖、排名第三)


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